Polynucleotides, reagents, and methods for nucleic acid hybridization

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United States of America Patent

PATENT NO 11732294
APP PUB NO 20200102611A1
SERIAL NO

16590301

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Abstract

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Provided herein are compositions, methods and systems relating to libraries of polynucleotides such that the libraries allow for accurate and efficient hybridization after binding to target sequences. Further provided herein are probes, blockers, additives, buffers, and methods that result in improved hybridization. Such compositions and methods are useful for improvement of Next Generation Sequencing applications, such as reducing off-target binding or reducing workflow times.

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Patent Owner(s)

Patent OwnerAddress
TWIST BIOSCIENCE CORPORATION681 GATEWAY BOULEVARD SOUTH SAN FRANCISCO CA 94080

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Butcher, Kristin D San Francisco, US 4 62
Chen, Siyuan San Mateo, US 85 2037
Chilton, E Hutson San Francisco, US 3 50
Gantt, Richard San Francisco, US 7 98
Zeitoun, Ramsey Ibrahim San Francisco, US 14 666

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