SUGAR-LINKED AMINO ACIDS FOR SOLID-PHASE PEPTIDE SYNTHESIS
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United States of America Patent
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Oct 8, 2020
app pub date -
Oct 8, 2018
filing date -
Oct 9, 2017
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Abstract
The present disclosure relates to sugar-linked amino acids and processes for preparing the same. The sugar-linked amino acids may be used for solid-phase peptide synthesis. A sugar compound and an amino acid compound having a nucleophilic side chain are reacted in a heated halogenated solvent. The reaction is catalyst by a Lewis acid, such as InBr3. The reaction is performed as a batch or continuous process.
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