Monosaccharide amine and 3-nitro-2-phenyl-2H-chromene based inhibitors of glucose kinases

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United States of America Patent

PATENT NO 11059842
APP PUB NO 20200339619A1
SERIAL NO

16859007

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Inhibitor compounds with biological activity against kinetoplastid parasites, along with methods of use of the compounds, are provided. The compounds can be used to strongly inhibit key drug targets found in protozoan parasites, e.g., the target Trypanosoma cruzi glucokinase. Compounds include derivatives of 3-nitro-2-phenyl-2H-chromene, and monosaccharide amines including D-glucosamine, D-mannosamine, D-galactosamine, and D-fructosamine.

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Patent OwnerAddress
UNIVERSITY OF SOUTH CAROLINAOSBORNE ADMINISTRATION BUILDING SUITE 109 COLUMBIA SC 29208

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
D'Antonio, Edward Bluffton, US 2 0

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