Method for processing polynucleotide-containing samples

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United States of America Patent

PATENT NO 11441171
APP PUB NO 20210047676A1
SERIAL NO

16832997

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Abstract

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Methods and systems for processing polynucleotides (e.g., DNA) are disclosed. A processing region includes one or more surfaces (e.g., particle surfaces) modified with ligands that retain polynucleotides under a first set of conditions (e.g., temperature and pH) and release the polynucleotides under a second set of conditions (e.g., higher temperature and/or more basic pH). The processing region can be used to, for example, concentrate polynucleotides of a sample and/or separate inhibitors of amplification reactions from the polynucleotides. Microfluidic devices with a processing region are disclosed.

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Patent Owner(s)

Patent OwnerAddress
HANDYLAB INC1 BECTON DRIVE FRANKLIN LAKES NJ 07417-1880

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Althaus, John S Saline, US 25 1031
Brahmasandra, Sundaresh N Ann Arbor, US 62 5963
Haley, Cecelia Canton, US 12 921
Handique, Kalyan Ann Arbor, US 234 15593
Kehrer, Aaron Ypsilanti, US 35 1805
Parunak, Gene Saline, US 65 4159
Phadke, Nikhil Ann Arbor, US 22 1821
Springer, Ted Ann Arbor, US 7 544
Wu, Betty Canton, US 35 2967

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