RANDOMIZED CONFIGURATION TARGETED INTEGRATION OF NUCLEIC ACIDS
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United States of America
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Apr 21, 2022
app pub date -
Dec 27, 2021
filing date -
Dec 27, 2021
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Abstract
The presently disclosed subject matter relates to “Randomized Configuration Targeted Integration” (also referred to herein as “Randomized Chain Targeted Integration”) (RCTI) strategies for the generation and identification of host cells capable of expressing recombinant proteins, e.g., monoclonal antibodies, as well as compositions derived from the same, e.g., bispecific antibodies, and other complex format proteins, e.g., membrane protein complexes and other difficult to express molecules.
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