MULTIVALENT CHLOROTOXIN CHIMERIC ANTIGEN RECEPTORS
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United States of America Patent
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Issued Date -
Aug 18, 2022
app pub date -
Jan 20, 2022
filing date -
Jan 20, 2021
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Abstract
Described are γδ T-cells that express a multivalent CLTX-CAR and also express a survival factor, a population of the γδ T-cells that express a multivalent CLTX-CAR and the survival factor, pharmaceutical compositions thereof, and methods of treating cancer or a tumor in a subject comprising administering to a subject an effective amount of the multivalent CLTX-CAR γδ T-cells and co-administering a chemotherapeutic agent, e.g., the chemotherapeutic agent to which the survival factor confers resistance.
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