METHODS FOR POLYMORPHIC SCREENING
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United States of America Patent
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Mar 9, 2023
app pub date -
Jan 14, 2021
filing date -
Jan 21, 2020
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Abstract
A method for screening a target compound for polymorphic forms is provided. The method comprises providing a library of mixed-crystal seeds, each mixed-crystal seed consisting essentially of the target compound and at least one structural analog that is structurally analogous to the target compound; and for each mixed-crystal seed: introducing the mixed-crystal seed into a crystallization medium comprising the target compound, under conditions suitable for crystallization of the target compound; monitoring the formation of crystals of the target compound; and when formed, characterizing the crystals of the target compound.
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