RANDOMIZED CONFIGURATION TARGETED INTEGRATION OF NUCLEIC ACIDS
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United States of America Patent
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Sep 7, 2023
app pub date -
Apr 3, 2023
filing date -
Jun 26, 2019
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Abstract
The presently disclosed subject matter relates to “Randomized Configuration Targeted Integration” (also referred to herein as “Randomized Chain Targeted Integration”) (RCTI) strategies for the generation and identification of host cells capable of expressing recombinant proteins, e.g., monoclonal antibodies, as well as compositions derived from the same, e.g., bispecific antibodies, and other complex format proteins, e.g., membrane protein complexes and other difficult to express molecules.
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