SOLVENT-FREE LIQUID FROM REGENERATED SILK FIBROIN: A WRITEABLE AND SHAPEABLE MATERIAL
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United States of America Patent
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Nov 23, 2023
app pub date -
May 23, 2023
filing date -
May 23, 2022
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Abstract
The present invention provides a solvent-free viscoelastic RSF liquid by modifying the RSF surface with polyethylenimine and polyethylene glycol-based polymer surfactant, which surrounds each RSF molecule by forming a dual shell and thereby minimizes the inter RSF interactions and thus prevents formation of β-sheet aggregation. The engineering of RSF surface with PEI and PS significantly improved the conformational stability and storage time of RSF liquid compared to native RSF as silk I conformation of RSF liquid remained intact for more than 8 months.
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