ANDROGEN RECEPTOR MODULATORS
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United States of America Patent
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Issued Date -
Dec 28, 2023
app pub date -
Mar 15, 2021
filing date -
Mar 15, 2021
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Abstract
The present disclosure relates to polycyclic (e.g., tetracyclic) androgen receptor (AR) modulators, synthetic methods for preparing such AR modulators, and methods of using such AR modulators to treat an androgen-dependent condition, such as prostate cancer or BPH. Exemplary compounds have quaternary centers at C9 and C13 in which the quaternary center at C9 projects a substituent on the opposite face of the tetracycle as the substituent at C13.
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