Importance

Loading Importance Indicators...

Abstract

Pharmaceutical formulations, methods for spray drying pharmaceutical formations, and systems for spray drying pharmaceutical formulation are provided. In one example, a method for spray drying a pharmaceutical formulation may include selecting a solvent mixture comprising a low volatility solvent based on a solubility of a drug of the pharmaceutical formulation in the solvent mixture, forming a solution of the drug of the pharmaceutical formulation in the solvent mixture, and spray drying the solution using a spray drying mass ratio that is selected based on a relationship between a glass transition temperature of the pharmaceutical formulation and a relative saturation of the low volatility solvent during the spray drying, the spray drying mass ratio defining a liquid feed rate of the solution to a gas feed rate of a drying gas, and using a process outlet temperature that is less than the glass transition temperature of the pharmaceutical formulation.

Loading the Abstract Image...

First Claim