ANTIBIOTICS WITH IMPROVED DRUG RESISTANCE PROFILE
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United States of America Patent
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Issued Date -
Apr 4, 2024
app pub date -
Jan 13, 2022
filing date -
Jan 14, 2021
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Abstract
Novel Fusidic Acid (FA) based compounds that have equivalent potency against clinical isolates of Staphylococcus aureus (S. aureus) and Enterococcus faecium (E. faecium) as well as an improved resistance profile in vitro when compared to FA. Importantly, the new compounds display efficacy against a FA-resistant strain of Staphylococcus aureus in a soft-tissue murine infection model. This disclosure delineates the structural features of FA necessary for potent antibiotic activity and demonstrates that the resistance profile can be improved for this scaffold and target.
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