Synergistic Inhibition of eIF5A and Notch Signaling
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United States of America Patent
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May 9, 2024
app pub date -
Jul 17, 2023
filing date -
Jul 17, 2023
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Abstract
Methods for inducing plasticity in effector T cells to exhibit a regulatory T cell phenotype, treating an autoimmune disease, enriching Treg cells, and preparing a subject for an organ transplant are described. The methods involve the synergstic inhibition of eIF5A and Notch signaling. Also described are compositions and kits including an eIF5A inhibitor and a Notch signaling inhibitor.
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