COMPOUNDS FOR ALTERING LEVELS OF ONE OR MORE NKA ALPHA SUBUNITS AND THEIR USE IN TREATING PRION DISEASES OR BRAIN DISEASES ASSOCIATED WITH CELLULAR PRION PROTEIN
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United States of America Patent
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Issued Date -
May 23, 2024
app pub date -
Mar 10, 2022
filing date -
Mar 10, 2021
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Abstract
The present application relates to methods for treating and/or preventing prion diseases and/or brain diseases, disorders or conditions that benefit from reduced levels of the cellular prion protein (PrPC) and/or altered levels of NKA alpha subunits comprising administering and effective amount of one or more agents that alter levels of one or more NKA alpha subunits, in a subject in need thereof, wherein each NKA alpha subunit with altered levels is a different paralog. The one or more agents are, for example, one or more compounds of Formula I, or a pharmaceutically acceptable salt and/or solvate thereof.
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