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Abstract

A terminally sterilized isotope generator for producing an alpha-emitting Lead-212 (²¹²Pb) daughter isotope by emanation of Radon-220 (²²⁰Rn) gas from Radium-224, comprising a closed retainer assembly including a parent-isotope chamber for receiving a parent isotope, a daughter-isotope chamber for collecting the ²¹²Pb daughter isotope, and a gas permeable membrane separating the parent-isotope chamber from the daughter-isotope chamber, wherein the parent isotope is naturally decaying into ²²⁰Rn within the parent-isotope chamber, wherein the gas permeable membrane allows the ²²⁰Rn to passively pass therethrough, wherein the ²²⁰Rn is spontaneously decaying into ²¹²Pb within the daughter-isotope chamber. An eluent is delivered in the daughter-isotope chamber, to elute in a liquid form the ²¹²Pb generated in a gaseous form; and a collection container collects the ²¹²Pb daughter-isotope eluted. The isotope generator is scalable based on required ²¹²Pb daughter-isotope quantities to be generated, the ²¹²Pb daughter-isotope quantities ranging from 1 mCi to 500 mCi.

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First Claim