Importance

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Abstract

Embodiments of the present disclosure include, for example, a medical device system is provided and includes an analyte diffusive implantable device (ADID), which comprises a cavity, a cell-scaffolding material (CSM) arranged within the cavity and configured to hold or otherwise retain a plurality of living cells engineered to secrete a therapeutic protein-based drug, and a porous hollow fiber membrane at least partially enclosing the cavity, where at least a portion of the membrane is adhered to the CSM by a high durometer adhesive which creates a hemispheric seal at both ends of the membrane, and a filling port having a docking means at a first end, and a micro-diameter tube (MDT) extending from a second end. The MDT is sealed at a distal end to the filling port and at a proximal end to the cavity of the ADID, so as to establish an integral, cell-filling pathway there-within.

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First Claim