COMPOSITION FOR PREVENTING OR TREATING OBESITY COMPRISING POLY-y-GLUTAMIC ACID ISOLATED FROM BACILLUS AS ACTIVE INGREDIENT

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United States of America Patent

APP PUB NO 20240238234A1
SERIAL NO

18480145

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Abstract

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An object of the present disclosure is to provide a composition for preventing or treating obesity comprising a substance isolated from poly-γ-glutamic acid (γ-PGA) as an active ingredient. According to the present disclosure, it was confirmed that γ-PGAbm or γ-PGAcm, a substance isolated from γ-PGA, suppressed the expression of adipogenic marker genes in 3T3-L1 cells to reduce accumulation of lipid droplets and triglycerides, and suppressed the expression of cell cycle regulators in the early stage of adipogenesis to reduce adipocyte differentiation. In addition, γ-PGAbm or γ-PGAcm has been confirmed to suppress obesity through weight loss, positive changes in glucose and insulin resistance, reduction of epididymal adipocytes, and suppression of adipogenesis, and thus may be used effectively for related businesses.

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Patent Owner(s)

Patent OwnerAddress
PUKYONG NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION45 YONGSO-RO NAM-GU BUSAN 48513 48513

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Jang, Won-Je Busan, KR 1 0
LEE, Jong-Min Busan, KR 200 1370
Oh, Dong-Nyoung Busan, KR 1 0

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