CHEMICALLY LINKABLE NUCLEAR TARGETING TAGS
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United States of America Patent
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Issued Date -
Jul 25, 2024
app pub date -
May 4, 2022
filing date -
May 4, 2021
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Abstract
Nuclear targeting tags having a phenylboronate targeting moiety, a linker, a chemically linkable end group suitable for linking the targeting moiety to a molecule of interest, and optionally a spacer between the linker and chemically linkable end group. Also provided are compounds including the nuclear targeting tag covalently bonded to a molecule of interest, such as a drug, probe, dye, peptide, protein, drug candidate, or natural product. Also provided are methods of introducing a molecule of interest into a nucleus of a cell using the nuclear targeting tag. Also provided are methods for preparing the nuclear targeting tags.
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