ENGINEERED TISSUE CONSTRUCTS AND USES THEREOF
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United States of America Patent
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Aug 22, 2024
app pub date -
Apr 25, 2024
filing date -
Oct 25, 2021
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Abstract
The present disclosure provides engineered tissue constructs having hepatocytes and stromal cells and methods of making and using the same (e.g., for treating acute liver failure, a urea cycle disorder, or hyperbilirubinemia (e.g., in a subject having Crigler-Najjar syndrome) in a human subject in need thereof). The engineered tissue constructs may provide a microenvironment that promotes the persistence of hepatocyte survival for at least three months.
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