METHODS OF DETECTING METHYLCYTOSINE AND HYDROXYMETHYLCYTOSINE BY SEQUENCING

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United States of America Patent

APP PUB NO 20240294967A1
SERIAL NO

18569532

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Abstract

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Embodiments of the present disclosure relates to various bisulfite-free chemical methods for detecting methylation of cytosine in the DNA sample. These methods convert methylated and hydroxymethylated cytosine in the nucleic acid sequence to a modified or pseudo thymine or a uracil moiety which then can be detected in sequencing.

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Patent Owner(s)

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ILLUMINA CAMBRIDGE LIMITEDCAMBRIDGE CB21 6DF

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
FRANCAIS, Antoine Cambridge, GB 25 35
LIU, Xiaohai Cambridge, GB 106 4424
WU, Xiaolin Cambridge, GB 94 1787

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