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United States of America Patent
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Issued Date -
Sep 12, 2024
app pub date -
Apr 29, 2024
filing date -
Jan 3, 2016
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Abstract
The present invention discloses a recombinant bacteriophage comprising a phage genome polynucleotide including a gene encoding a heterologous antigen protein(s) and a killing gene encoding a protein that is capable of killing a host bacterium. Such a recombinant bacteriophage is designed to prime a subject's immune response and to kill the bacterium that it infects such that the “prime and kill” bacteriophage provides two lines of protection against infectious disease.
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