FORMULATIONS OF ACTIVE PHARMACEUTICAL INGREDIENTS (APIs) FOR LOCAL DELIVERY VIA ACTIVE MICROBOT
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United States of America Patent
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Issued Date -
Sep 19, 2024
app pub date -
Jun 13, 2022
filing date -
Jun 23, 2021
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Abstract
Provided herein are pharmaceutical formulations, methods of manufacturing thereof, and methods of treatment. The pharmaceutical formulations are adapted to serve as a pay load on or in a microbot, and comprise a tablet of a therapeutically effective dose of a pharmaceutical agent and have dimensions such that the tablet may fit on or in the microbot. The pharmaceutical formulation may be formed into, e.g., a cylinder or spheroid of 1 mm dimension, and the pharmaceutical agent may be a small molecule drug, a peptide, a peptoid, a biologic drug, cells, or any combination thereof. Thus, the pharmaceutical formulation of the present description offers delivery of targeted therapy at a locus in a subject, e.g., a tumor.
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