PERINAPHTHENONE COMPOUND AND USE THEREOF
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United States of America Patent
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Issued Date -
Oct 17, 2024
app pub date -
Sep 6, 2022
filing date -
Sep 6, 2022
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Abstract
Disclosed in the present invention are a perinaphthenone compound and the use thereof. The compound can bind to E3 ubiquitin ligase tripartite motif 25 (TRIM25), thereby facilitating the recognition of TRIM25 to a pathogen and inducing proteasome-dependent ubiquitination degradation of the pathogen protein. The compound is expected to be used as a ligand for TRIM25 and have a broad application, for example, for preparing a PROTAC molecule. Therefore, the compound has good research and development value and application prospects.
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