COMPOSITIONS AND METHODS FOR TARGETED DEGRADATION OF PROTEINS IN A PLANT CELL
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United States of America
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Nov 7, 2024
app pub date -
Aug 31, 2022
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Aug 31, 2022
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Abstract
Compounds, compositions, and methods for controlling the level of a target protein in a cell are described. Compounds of the disclosure include those having according to the formula PTM-L-LTM, wherein PTM is a targeting moiety that binds the target protein, L is a covalent bond or linker moiety, and LTM is a ubiquitin ligase binding moiety that binds a plant ubiquitin ligase. Additionally novel cereblon binding moieties are provided that may be used as molecular glues or in bifunctional compounds to target proteins in plants and mammals.
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