SELECTIVE ISONITRILE INHIBITORS OF CYTOCHROME P450 SUBTYPES
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United States of America
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Nov 7, 2024
app pub date -
Aug 25, 2022
filing date -
Aug 25, 2022
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Abstract
Described herein are steroid or steroid-like compounds including at least one isonitrile group and which inhibit the activity of a cytochrome P450 enzyme, as well as compositions including the compounds. Also included are methods of inhibiting activity of a cytochrome P450 in a subject having a steroid-responsive cancer, a Mycobacterium tuberculosis infection, a fungal infection, or a trypanosome infection, the method comprising administering to the subject the compound including at least one isonitrile group or a pharmaceutically acceptable salt thereof, in an amount effective to inhibit the CYP activity in the subject.
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