WATER-SOLUBLE ALLOPREGNANOLONE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF
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United States of America
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Issued Date -
Nov 21, 2024
app pub date -
Sep 13, 2022
filing date -
Sep 13, 2022
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Abstract
A compound represented by formula I, a racemate, a stereoisomer, a tautomer, a solvate, a polymorph, or a pharmaceutically acceptable salt thereof are provided. In formula I, R2 and R4 are independently selected from H or D, respectively; R1 and R3 are independently selected from CH3, CH2D, CHD2 or CD3, respectively; and the compound of formula I contains at least one deuterium atom. While retaining the pharmacological activity of the allopregnanolone, an allopregnanolone derivative that is suitable for oral administration is obtained by means of the structural modification on the hydroxyl group of the allopregnanolone.
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