METHODS FOR HIGH-RESOLUTION GENOME-WIDE FUNCTIONAL DISSECTION OF TRANSCRIPTIONAL REGULATORY REGIONS

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United States of America

APP PUB NO 20240384258A1
SERIAL NO

18667037

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Abstract

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Embodiments disclosed herein provide a general, scalable, high-throughput, and high-resolution approach for experimental dissection of regulatory regions and driver nucleotides in the context of human biology and disease. Applicants present HiDRA, a novel high-resolution global screen for transcriptional regulatory activity in accessible chromatin regions, enabling high-efficiency, high-throughput, and high-resolution inference of regulatory activity.

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Patent Owner(s)

Patent OwnerAddress
BETH ISRAEL DEACONESS MEDICAL CENTER INC330 BROOKLINE AVENUE BOSTON MA 02215

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Claussnitzer, Melina Boston, US 5 0
He, Liang Cambridge, US 84 370
Kellis, Manolis Cambridge, US 9 98
Wang, Xinchen Cambridge, US 3 0

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