ANTIBODY AFFINITY MATURATION USING NATURAL LIABILITY-FREE CDRS
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United States of America
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Nov 21, 2024
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Jul 7, 2022
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Jul 7, 2022
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Abstract
Provided herein is an improved method of antibody affinity maturation that uses true natural CDRs from a population of naturally occurring antibodies targeting a single antigen or antigenic epitope such that the improved method produces functional antibodies having low-picomolar affinity antibodies. Also provided herein is an antibody library where the CDRs within a single antibody member of the library are a combination of CDR sequences of naturally occurring antibodies and one or more CDRs are derived from different naturally occurring antibodies targeting a single antigen or antigenic epitope.
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