HYDROPHILIC LINKERS FOR ANTIBODY DRUG CONJUGATES
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United States of America
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Dec 12, 2024
app pub date -
Jul 26, 2024
filing date -
Jul 26, 2024
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Abstract
Described herein protein drug conjugates and compositions thereof that are useful, for example, for the target-specific delivery of drugs to cells. By administering these compounds, compositions, and conjugates as described herein to specific target cells, side-effects due to non-specific binding phenomena, for example, to non-target cells are reduced. In certain embodiments, compounds, compositions, and conjugates are provided, which include hydrophilic residues in linker-payloads and protein conjugates thereof.
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