HIGH-EFFICACY LABELING OF ANTIBODIES WITH OLIGONUCLEOTIDE LABELS
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United States of America
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Jan 9, 2025
app pub date -
Nov 14, 2022
filing date -
Nov 14, 2022
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Abstract
The invention comprises a method for highly efficient selective labelling of antibodies with oligonucleotides. The method may involve the selective removal of glycans from the antibody and replacing them by artificial glycosides, especially N-glycosides including oligonucleotides. The process is believed to be facilitated by the oligonucleotide induced orientation of the antibody C′E loop and to a lesser extent by the Cγ2-Cγ3 domain. The method results in the high efficacy labelling of antibodies.
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