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Abstract

Provided is a method of producing hydroxypropyl methylcellulose acetate succinate powder capable of inhibiting aggregation of particles of the precipitated esterified cellulose ether and reducing produced amount of fine powder to thereby obtain the esterified cellulose ether in high yield. The method of producing hydroxypropyl methylcellulose acetate succinate powder comprises an esterification reaction step, a precipitation step, a washing/recovering step and a drying step, wherein the precipitation step is a step of introducing the reaction solution, obtained in the esterification reaction step, and water into a mixer provided with a rotatable rotor having blades and a perforated plate arranged to surround the rotor in a direction perpendicular to a radial direction of the rotor to allow a suspension, containing precipitated hydroxypropyl methylcellulose acetate succinate particles, to pass through the perforated plate to be discharged therethrough.

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First Claim