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Abstract

Described herein is a delivery system that targets leukocytes and in some embodiments monocytes to deliver nucleic acid encoding a chimeric antigen receptor. Additionally, described herein is a method of using a delivery system to transduce leukocytes and in some embodiments monocytes to deliver nucleic acid encoding a chimeric antigen receptor. The delivery system may also function to activate the target cell by providing a ligand to the chimeric antigen receptor. Furthermore, described herein is a delivery system that also include a nucleic acid inhibitor that decreases the expression of a protein that forms a part of the pathway that degrades the chimeric receptor. In embodiments, the binding of a ligand to the extracellular domain of the chimeric receptor activates the intracellular portion of the chimeric receptor. Activation of the intracellular portion of the chimeric receptor may polarize the macrophage into an M1 or M2 macrophage.

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First Claim