MODULATION OF NICOTINE PRODUCTION BY ALTERATION OF NICOTINAMIDASE EXPRESSION OR FUNCTION IN PLANTS

Number of patents in Portfolio can not be more than 2000

United States of America

APP PUB NO 20250084427A1
SERIAL NO

18722452

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Abstract

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There is described herein a plant cell having modulated expression or activity of a nicotinamidase enzyme, said plant cell comprising: (a) a polynucleotide sequence comprising, consisting or consisting essentially of a sequence encoding the nicotinamidase enzyme; or (b) a polypeptide encoded by the polynucleotide set forth in (a); wherein said plant cell comprises at least one modification which modulates the expression or activity of the polynucleotide or the polypeptide as compared to a control plant cell in which the expression or activity of the polynucleotide or polypeptide has not been modified. Furthermore, said poly nucleotide (a) of said plant cell comprises: (i) a polynucleotide comprising, consisting or consisting essentially of a sequence having at least 70% sequence identity to SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7, SEQ ID NO:9, SEQ ID NO:11, SEQ ID NO:13, SEQ ID NO:15, SEQ ID NO:17, SEQ ID NO:19 SEQ ID NO:24 or SEQ ID NO:26; and/or (ii) a construct, vector or expression vector comprising the isolated polynucleotide set forth in (i) or set forth in SEQ ID NO:21. Furthermore, wherein said polypeptide (b) of said plant cell comprises: a polypeptide encoded by the polynucleotide set forth above; and/or a polypeptide comprising, consisting or consisting essentially of a sequence having at least 90% sequence identity to SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18, SEQ ID NO:20, SEQ ID NO:25 or SEQ ID NO:27.

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Patent Owner(s)

Patent OwnerAddress
PHILIP MORRIS PRODUCTS S A2000 NEUCHÂTEL

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
BOVET, Lucien La Chaux-de-Fonds, CH 21 13
HILFIKER, Aurore Salavaux, CH 7 0

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