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Abstract

The subject invention pertains to a nanopore sensing device for inertial-kinetic translocation and sensing of single molecules. Some embodiments comprise a centrifuge rotor; a centrifuge tube; single or multiple flow cell modules; a nanopore module consisting of single or multiple nanopores; a signal detection module; a signal amplifier module; a control module; and a wireless communication module. Through the kinetic regulation of a centrifugal force field while maintaining a counter-balanced state of electrophoretic and electroosmotic forces in the nanopore by adjusting the pH value of the electrolyte in nanopore or the surface charge excited on the silicon nanopore using visible light, the precise regulation of molecular translocation parameters, such as speed, direction, and molecular selectivity, is provided for optimizing the temporal and spatial resolutions of molecular sensing with high S/N ratio signal readout.

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First Claim