Importance

Loading Importance Indicators...

Abstract

The present invention relates to a marked fatty acid derivative, a precursor compound thereof, and use thereof in a contrast agent. The derivative is represented by formula I: wherein M is ^99mTc or Re; R, R¹, R², R³, R⁴ and R⁵, and A₁-A₁₂ are independently H, an aliphatic chain or an alicyclic; J, X, and Y are independently absent, or —O—, —S— or (II), and J, X, and Y are not simultaneously absent; R⁶-R¹⁴ are independently H or an aliphatic chain, and R¹³ and R¹⁴ are not H simultaneously; z is 1-6, a is 0-5, b is 0-5, and c is 0-3; d is 0-27, e is 0-27, f is 0-28, g is 0-7, and at least two of d, e, f and g are not 0. The present invention provides a completely novel structure type that can be used for preparing a novel myocardial metabolism contrast agent, possessing important clinical application prospects.

Loading the Abstract Image...

First Claim