MASKED IL12 PROTEIN
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United States of America
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Issued Date -
Apr 10, 2025
app pub date -
Feb 15, 2023
filing date -
Feb 15, 2023
priority date (Note) -
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Abstract
Disclosed herein are masked IL12 proteins that can be activated both in vitro and in vivo. Surprisingly, a small, bioorthogonal group is sufficient to deactivate or mask the IL12 protein, which can thereafter be activated by contacting the masked IL12 protein with the bioorthogonal reactive partner of the Trigger joining the IL12 protein to the mask (either a dienophile or a diene). The invention also relates to methods for using and preparing said masked IL12 proteins.
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