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Abstract

The disclosure relates to the technical filed of organic synthesis, in particular to a method for preparing veratrole. In the disclosure, veratrole is prepared by using lithium hydroxide instead of sodium hydroxide, catechol as raw material, and dimethyl sulfate as methylating agent. Comparing with the existing method of adding sodium hydroxide solution, the method according to the disclosure allows reduced reaction temperature, shortened reaction time, and thereby improves the stability and safety of the reaction and the product yield. The experimental data of the examples in the disclosure shows a veratrole yield up to 95%. Furthermore, the preparation method according to the disclosure does not need to be carried out under a reflux condition, the operation of which is simpler, thereby further improving the safety and stability of the reaction.

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First Claim