GINGERENONE A PRODRUGS AS SENSOTHERAPEUTICS AND METHODS OF USE
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United States of America
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Apr 10, 2025
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Jan 17, 2023
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Jan 17, 2023
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Abstract
Gingerenone A prodrug compounds have a structure according to Formula I, or a pharmaceutically acceptable salt thereof wherein one of R1 and R2 is H or —C(O)—R and the other of R1 and R2 is —C(O)—R. Each R independently is RA or, where RA is C18-C22 alkenyl, and RB is an amino acid side chain. The compounds are useful for inhibiting or eliminating senescence. The compounds may be administered to a subject having a senescence-associated disease or disorder, neuroinflammation, pain, and/or an amino acid deficiency.
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