DPO4 POLYMERASE VARIANTS
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United States of America
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Apr 10, 2025
app pub date -
May 28, 2024
filing date -
May 28, 2024
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Abstract
Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.
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