Process for coupling biological substances by covalent bonds
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United States of America Patent
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-
Mar 18, 1980
Grant Date -
N/A
app pub date -
Dec 1, 1976
filing date -
Dec 5, 1975
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A process for coupling biological substances by covalent bonds that involves the use of benzoquinone as cross-linking agent in large excess compared with the substance to be activated. The activation reaction is realized in a homogeneous liquid medium. The process makes it possible, for example, to couple antibodies to enzymes for determining or detecting said antibodies. The process can be used for the determination of antitetanic antibodies in human serum.
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