US Patent No: 4,197,316
Number of patents in Portfolio can not be more than 2000
Treatment of dry skin
Stats
-
Apr 8, 1980
Issued date -
Jan 17, 1978
filing date -
05/870,114
serial no -
Expired
status
Importance
Loading Importance Indicators...
Overall
|
US Family Size
|
International Coverage
|
Patent Longevity
|
Forward Citations
|
Abstract
Preventive as well as therapeutic treatment to alleviate the symptoms of disorders characterized by cracking, flaking or scaling of the skin consisting of the topical application of a lotion, cream or ointment containing one or more of the .alpha.- or .beta.-hydroxy acids or .alpha.-keto acids and esters thereof, their amides and their ammonium salts is disclosed. The compounds include free acid, amide and/or ammonium salt forms of citric acid, glycolic acid, glucuronic acid, galacturonic acid, glucuronolactone, gluconolactone, .alpha.-hydroxybutyric acid, .alpha.-hydroxyisobutyric acid, lactic acid, malic acid, mandelic acid, mucic acid, pyruvic acid, methyl pyruvate, ethyl pyruvate, .beta.-phenyllactic acid, .beta.-phenylpyruvic acid, saccharic acid, tartaric acid, tartronic acid, and .beta.-hydroxybutyric acid. The therapeutic composition may include one or more of the compounds present in the total amount of from one to twenty percent. Topical application to affected areas has been found to achieve amelioration of the dry skin.
Loading the Abstract Image...
First Claim
Related Publications
Loading Related Publications...
- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
- Assignment data not available. Check USPTO
International Classification(s)
- [Classification Symbol]
- [Patents Count]
Inventor(s)
| Inventor Name | Address | # of filed Patents | Total Citations |
|---|---|---|---|
| Van, Scott Eugene J | Abington, PA | 145 | 2126 |
| Yu, Ruey J | Chalfont, PA | 164 | 2423 |
Cited Art
- No Cited Art to Display
Patent Citation Ranking
Forward Cites
| Patent Info | (Count) | # Cites | Year |
|---|---|---|---|
|
|
|||
| 5,385,938 Method of using glycolic acid for treating wrinkles | 69 | 1992 | |
| 5,665,776 Additives enhancing topical actions of therapeutic agents | 30 | 1993 | |
| 5,389,677 Method of treating wrinkles using glycalic acid | 57 | 1993 | |
| 5,702,688 Amphoteric compositions and polymeric forms of alpha hydroxyacids, and their therapeutic use | 17 | 1993 | |
| 5,470,880 Method of using citric acid for the treatment of wrinkles | 38 | 1994 | |
| 5,422,370 Method of using 2-hydroxypropanoic acid (lactic acid) for the treatment of wrinkles | 36 | 1994 | |
| 5,547,988 Alleviating signs of dermatological aging with glycolic acid, lactic acid or citric acid | 42 | 1994 | |
| 5,670,541 Method of treating wrinkles using gulonic acid or gulonolactone | 1 | 1995 | |
| 5,668,177 Method of treating wrinkles using tartaric acid | 1 | 1995 | |
| 5,591,774 Method of treating wrinkles using malic acid | 3 | 1995 | |
| 5,589,505 Method of treating wrinkles using quinic acid or quinolactone | 7 | 1995 | |
| 5,561,155 Method of treating wrinkles using galacturonic acid or galacturonolactone | 1 | 1995 | |
| 5,561,159 Method of treating wrinkles using tropic acid | 1 | 1995 | |
| 5,550,154 Method of treating wrinkles using glucuronic acid or glucuronolactone | 1 | 1995 | |
| 5,716,992 Method of using mucic acid or mucolactone for treating wrinkles | 1 | 1995 | |
| 5,677,339 Method of using mandelic acid for treating wrinkles | 1 | 1995 | |
| 5,677,340 Method of using gluconic acid or gluconolactone for treating wrinkles | 3 | 1995 | |
| 5,674,899 Method of using lactic acid for treating wrinkles | 1 | 1995 | |
| 5,674,903 Method of using citric acid for treating wrinkles | 1 | 1995 | |
| 5,670,542 Method of using glucuronic acid or glucronolactone for treating wrinkles | 1 | 1995 | |
| 5,670,543 Method of using pantoic acid or pantolactone for treating wrinkles | 1 | 1995 | |
| 5,656,665 Method of using quinic acid or quinolactone for treating wrinkles | 6 | 1995 | |
| 5,656,666 Method of using ribonic acid or ribonolactone for treating wrinkles | 1 | 1995 | |
| 5,654,340 Method of using gulonic acid or gulonolactone for treating wrinkles | 2 | 1995 | |
| 5,652,267 Method of using saccharic acid or saccharolactone for treating wrinkles | 1 | 1995 | |
| 5,650,436 Method of using galactonic acid or galactonolactone for treating wrinkles | 1 | 1995 | |
| 5,650,437 Method of using benzilic acid for treating wrinkles | 1 | 1995 | |
| 5,650,440 Method of using citramalic acid for treating wrinkles | 1 | 1995 | |
| 5,648,388 Method of using methyllactic acid for treating wrinkles | 1 | 1995 | |
| 5,648,391 Method of using galacturonic acid or galacturonolactone for treating wrinkles | 1 | 1995 | |
| 5,648,395 Method of using tartaric acid for treating wrinkles | 2 | 1995 | |
| 5,643,952 Method of using 2-phenyllactic acid for treating wrinkles | 1 | 1995 | |
| 5,643,953 Method of using 3-phenyllactic acid for treating wrinkles | 1 | 1995 | |
| 5,643,961 Method of using malic acid for treating wrinkles | 2 | 1995 | |
| 5,643,962 Method of using glucoleptonic acid for treating wrinkles | 1 | 1995 | |
| 5,643,963 Method of using isocitric acid for treating wrinkles | 1 | 1995 | |
| 5,612,376 Method of treating wrinkles using 3-phenyllactic acid | 1 | 1995 | |
| 5,599,843 Method of treating wrinkles using 2-phenyllactic acid | 1 | 1995 | |
| 5,583,156 Method of treating wrinkles using ribonic acid or ribonolactione | 2 | 1995 | |
| 5,580,902 Method of treating wrinkles using ethyl pyranate | 4 | 1995 | |
| 5,578,644 Method of treating wrinkles using isocitric acid | 1 | 1995 | |
| 5,574,067 Method of treating wrinkles using gluconic acid or gluconolactone | 1 | 1995 | |
| 5,571,841 Method of treating wrinkles using mandelic acid | 2 | 1995 | |
| 5,565,487 Method of treating wrinkles using galactonic acid or galactonolactone | 2 | 1995 | |
| 5,561,153 Method of treating wrinkles using mucic acid or mucolactone | 1 | 1995 | |
| 5,561,156 Method of treating wrinkles using methyllactic acid | 1 | 1995 | |
| 5,556,882 Methods of treating wrinkles using benzilic acid | 1 | 1995 | |
| 5,554,651 Method of treating wrinkles using citramalic acid | 1 | 1995 | |
| 5,550,158 Method of treating wrinkles using glucoheptonic acid | 1 | 1995 | |
| 5,942,250 Compositions and methods for enhancing the topical effects of sunscreen agents | 7 | 1995 | |
| 5,834,510 Compositions comprising 2-hydroxycarboxylic acids and related compounds, and methods for alleviating signs of dermatological aging | 2 | 1995 | |
| 5,690,967 Compositions for improved topical delivery of lactic acid | 7 | 1995 | |
| 5,691,378 Method for treating wrinkles using combinations of alpha hydroxyacids and/or alpha ketoacids | 3 | 1995 | |
| 5,686,489 Alpha hydroxyacid esters for skin aging | 9 | 1995 | |
| 5,684,044 Methods for improved topical delivery of lactic acid | 3 | 1995 | |
| 5,681,853 Methods for improved topical delivery of alpha hydroxyacids | 5 | 1995 | |
| 5,654,336 Methods of using glycolic acid for reversing or retarding the effect of aging on human facial skin | 4 | 1995 | |
| 5,571,837 Method of treating wrinkles using saccharic acid or saccharolactone | 1 | 1995 | |
| 5,561,158 Compositions comprising 2-hydroxycarboxylic acids and related compounds, and methods for alleviating signs of dermatological aging | 12 | 1995 | |
| 5,889,054 Method of using beta hydroxy acids for treating wrinkles | 18 | 1997 | |
| 5,962,526 Pharmaceutical compositions containing hydroxycarboxylic acids and/or ketocarboxylic acids and methods of using same | 1 | 1997 | |
| 5,856,357 Method for treating wrinkles using certain alpha hydroxyacids | 4 | 1997 | |
| 5,886,041 Amphoteric compositions and polymeric forms of alpha hydroxyacids, and their therapeutic use | 9 | 1997 | |
| 6,384,079 Compositions comprising 2-hydroxycarboxylic acids and related compounds, and methods for alleviating signs of dermatological aging | 8 | 1999 | |
| 6,191,167 Pharmaceutical compositions containing hydroxycarboxylic acid and/or ketocarboxylic acids and methods of using the same | 10 | 1999 | |
|
|
|||
| 5,856,364 Therapeutic antiviral-wound healing compositions and methods for preparing and using same | 17 | 1995 | |
| 5,863,938 Antibacterial-wound healing compositions and methods for preparing and using same | 9 | 1995 | |
| 5,663,208 Antifungal wound healing compositions and methods for preparing and using same | 34 | 1995 | |
| 5,658,956 Bioadhesive-wound healing compositions and methods for preparing and using same | 32 | 1995 | |
| 5,652,274 Therapeutic-wound healing compositions and methods for preparing and using same | 32 | 1995 | |
| 5,648,380 Anti-inflammatory wound healing compositions and methods for preparing and using same | 21 | 1995 | |
| 5,641,814 Antikeratolytic-wound healing compositions and methods for preparing and using same | 13 | 1995 | |
| 5,614,561 Antihistamine-wound healing compositions and methods for preparing and using same | 6 | 1995 | |
| 5,602,183 Dermatological wound healing compositions and methods for preparing and using same | 42 | 1995 | |
| 7,396,526 Skin care composition | 0 | 2000 | |
|
|
|||
| 5,045,308 Cosmetic composition | 6 | 1989 | |
| 5,216,033 Water-in-oil transparent emulsion for the skin | 46 | 1990 | |
| 5,196,187 Cosmetic composition | 28 | 1991 | |
| 5,914,116 Treatment regime for skin | 19 | 1996 | |
| 6,531,116 Treatment regime for skin | 4 | 1998 | |
|
|
|||
| 4,507,319 Skin treatment composition | 23 | 1983 | |
| 4,699,924 Skin treatment composition | 21 | 1984 | |
| 4,612,331 Skin treatment composition | 84 | 1985 | |
| 5,260,051 Compositions comprising phosphate ester compounds containing a beneficial reagent component | 13 | 1990 | |
| 5,366,665 Compositions comprising alkyl sulfooxyalkanoate compounds containing a beneficial reagent component | 8 | 1993 | |
|
|
|||
| 5,683,705 Sulfur-based amides and bis-amides useful against skin disorders | 2 | 1996 | |
| 5,948,418 Sulfur-based amides and bis-amides useful against skin disorders | 5 | 1997 | |
| 6,025,347 Steroid esters useful against skin disorders | 6 | 1998 | |
| 6,284,750 .alpha.-hydroxyacid esters of DHEA useful against skin disorders | 2 | 2000 | |
|
|
|||
| 5,674,912 Sunscreen-wound healing compositions and methods for preparing and using same | 39 | 1995 | |
| 5,658,957 Immunostimulating wound healing compositions and method for preparing and using same | 12 | 1995 | |
| 5,646,190 Acne treating-wound healing compositions and methods for preparing and using same | 15 | 1995 | |
| 5,633,285 Cytoprotective wound healing compositions and methods for preparing and using same | 7 | 1995 | |
|
|
|||
| 5,084,270 Cosmetic compositions containing N-alkoxyalkylamides | 24 | 1989 | |
| 5,139,784 Alkyl diamides and cosmetic treating compositions therewith | 3 | 1990 | |
| 5,306,489 Hair care products containing N-alkoxyalkylamides | 18 | 1992 | |
|
|
|||
| 5,256,697 Method of administering pyruvate and methods of synthesizing pyruvate precursors | 23 | 1992 | |
| 5,312,985 Method of synthesizing the precursor pyruvamide | 6 | 1993 | |
| 5,283,260 Method for reducing insulin resistance in mammals | 18 | 1993 | |
|
|
|||
| 5,759,557 Skin care composition | 3 | 1996 | |
| 5,759,558 Skin care composition | 7 | 1997 | |
|
|
|||
| 5,869,069 Lipophilic hydroxylated acid, its use in cosmetics and pharmacy, and its process of preparation | 1 | 1996 | |
| 6,039,961 Lipophilic hydroxylated acid, its use in cosmetics and pharmacy, and its process of preparation | 0 | 1998 | |
|
|
|||
| 5,411,734 Non-irritating .alpha.-hydroxy carboxylic acid compositions | 9 | 1993 | |
| 5,382,432 Cosmetic method for treatment of skin | 14 | 1993 | |
|
|
|||
| 4,956,110 Aqueous fluid | 6 | 1988 | |
| 4,938,891 Aqueous fluids | 8 | 1989 | |
|
|
|||
| 5,393,526 Cosmetic compositions | 14 | 1994 | |
| 5,505,935 Sunscreen compositions | 13 | 1994 | |
|
|
|||
| 5,492,932 Lubrication germicidal composition | 10 | 1994 | |
| 5,767,163 Lubricating and/or germicidal composition | 21 | 1996 | |
|
|
|||
| 5,759,555 Cosmetic formulation and method for amelioration of skin keratoses and striae distensae | 6 | 1996 | |
| 5,928,659 Cosmetic formulation and method for amelioration of skin keratoses and striae distensae | 15 | 1998 | |
|
|
|||
| 5,505,948 Home skin peel composition for producing healthy and attractive skin | 10 | 1993 | |
| 5,730,991 Home skin peel composition for producing healthy and attractive skin | 14 | 1996 | |
|
|
|||
| 5,885,593 Skin care composition including cyclodextrin materials and method for treating skin therewith | 15 | 1996 | |
|
|
|||
| 5,407,958 Therapeutic skin composition | 21 | 1993 | |
|
|
|||
| 5,798,388 Method and composition for treating mammalian diseases caused by inflammatory response | 6 | 1996 | |
|
|
|||
| 4,824,865 Treatment of skin disorders | 12 | 1987 | |
|
|
|||
| 5,692,302 Razor cartridges comprising wound healing compositions and methods for preparing and using same | 9 | 1995 | |
|
|
|||
| 5,262,153 Skin-whitening agent | 28 | 1990 | |
|
|
|||
| 4,775,530 Method for treatment and prevention of pseudofolliculitis barbae | 18 | 1987 | |
|
|
|||
| 6,159,480 Cosmetic makeup composition | 6 | 1997 | |
|
|
|||
| 7,723,387 Self-neutralizing acid peel for dermatologic use | 0 | 2006 | |
|
|
|||
| 7,402,323 Compositions and methods for treating skin conditions | 0 | 2003 | |
|
|
|||
| 5,451,401 Diphosphonic acid esters as tartar control agents | 15 | 1993 | |
|
|
|||
| 5,827,882 Method of using ethyl pyruvate for treating wrinkles | 3 | 1995 | |
|
|
|||
| 8,013,017 Dermatological compositions and methods | 0 | 2009 | |
|
|
|||
| 5,021,455 Solution for neutralizing caustic effects of alkaline cementitious materials on human skin | 0 | 1989 | |
| 5,006,557 Acne solution | 1 | 1990 | |
| 5,356,811 Method of processing stabilized aloe vera gel obtained from the whole aloe vera leaf | 17 | 1993 | |
| 5,627,187 5-FU for treating actinic kerotoses | 5 | 1995 | |
| 5,621,006 Method for treating acne using benzilic acid | 9 | 1995 | |
| 5,561,157 Method for enhancing the therapeutic effect of a composition comprising hydroquinone and comprising same | 18 | 1995 | |
| 5,554,597 Compositions comprising 2-hydroxycarboxylic acids and related compounds, and methods for alleviating signs of dermatological aging | 10 | 1995 | |
| 5,554,652 Method of treating wrinkles using alpha hydroxyacids, alpha ketoacids and a sunscreen agent | 4 | 1995 | |
| 5,554,654 Method for enhancing the therapeutic effect of an anti-acne agent | 29 | 1995 | |
| 6,335,023 Oligosaccharide aldonic acids and their topical use | 26 | 2000 | |
| 6,740,327 Oligosaccharide aldonic acids and their topical use | 7 | 2001 | |
| 7,452,545 Oligosaccharide aldonic acids and their topical use | 0 | 2004 | |
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|
| Fee | Large entity fee | small entity fee | micro entity fee |
|---|---|---|---|
| Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
| Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |