5-Substituted 1-(2'-Deoxy-2'-substituted-.beta.-D-arabinofuranosyl)pyrimidine nucleosides

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United States of America Patent

PATENT NO 4211773
SERIAL NO

05948189

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Abstract

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Pyrimidine nucleosides exhibiting anti-viral and anti-tumor effects have the formula ##STR1## wherein A is OR.sup.3, SR.sup.3, NR.sup.3 R.sup.4 or NHacyl wherein R.sup.3 and R.sup.4 are the same or different and are hydrogen, lower alkyl of 1 to 7 carbon atoms, aralkyl, or aryl; NHacyl is alkanoyl or aroyl amide; B is oxygen or sulfur; X is halogen, alkylsulfonyl or arylsulfonyl; Y is halogen, amino, monoalkyl- or monoaralkylamino, dialkylamino, aminomethyl, hydroxymethyl, lower alkyl, aryl, aralkyl, vinyl and substituted vinyl or ethynyl and substituted ethynyl; Z is methyne or nitrogen; R.sup.1 and R.sup.2 are the same or different and are hydrogen acyl or aroyl.

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Patent Owner(s)

  • SLOAN-KETTERING INSTITUTE FOR CANCER RES

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fox, Jack J White Plains, NY 7 315
Lopez, Carlos New York, NY 36 642
Reichman, Uri White Plains, NY 3 138
Watanabe, Kyoichi A Portchester, NY 37 789

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