Assay of serine proteases using novel chromogenic enzyme substrates

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United States of America Patent

PATENT NO 4214049
SERIAL NO

05955441

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Abstract

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Method for the quantitative determination of serine proteases which includes contacting the substance for which the determination is desired with a diagnostically active chromogenic substrate with good stability and high specificity to serine proteases having the formula: H--D--A.sub.1 --A.sub.2 --A.sub.3 --NH--R or salts thereof, wherein A.sub.1 is Gly, Ala, Val, Leu, Ile, Pip, Pro, or Aze; A.sub.2 is Gly, Ala, Val, Leu, Ile, Pip, Pro, Aze, or Phe; A.sub.3 is Arg, Lys, or Orn, and R is a chromophoric group.

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Patent Owner(s)

  • AB KABI

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
af, Ekenstam Bo T Molndal, SE 8 225
Aurell, Leif E Saro, SE 8 106
Claeson, Karl G Saro, SE 9 127
Gustavsson, Stig I Molndal, SE 3 38
Karlsson, Birgitta G Molndal, SE 2 22
Olausson, Gun A Vastra Frolunda, SE 1 8

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