Process for the preparation of liposomes in aqueous solution
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United States of America Patent
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Sep 23, 1980
Grant Date -
N/A
app pub date -
Aug 4, 1978
filing date -
Aug 5, 1977
priority date (Note) -
Expired
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Abstract
A process for the preparation of a solution or suspension of liposomes in an aqueous medium comprising the steps of dispersing a first aqueous liquid in an essentially water-insoluble solvent in the presence of a compound of the formula XY wherein X is a hydrophilic lipophobic group and Y is a lipophilic hydrophobic group to form a dispersion of liposome precursors in the solvent, the precursors consisting of small vesicles of the first aqueous liquid surrounded by a monomolecular film of compound XY, emulsifying the liposome precursors in a second aqueous medium in the presence of a compound of the formula ZW wherein Z is a hydrophilic group and W is a hydrophobic group to thereby form a solution or suspension of liposomes in the second aqueous medium, said liposomes consisting of the first aqueous liquid surrounded by a bimolecular film of the structure XY-WZ and removing the water-insoluble solvent prior to after said emulsification.
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