Azaprostanoic acid analogs and their use as inhibitors of platelet aggregation
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United States of America Patent
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Dec 16, 1980
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N/A
app pub date -
Sep 12, 1978
filing date -
Sep 12, 1978
priority date (Note) -
Expired
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Abstract
Novel azaprostanoic acid analogs of the formula ##STR1## wherein: R is C.sub.1 to C.sub.8 alkyl or benzyl; and a has a value of from 0 to 6 inclusive, and their pharmaceutically acceptable salts and esters. Preferred 13-aza and 15-aza compounds are active in the inhibition of arachidonic acid-induced platelet aggregation and, more specifically, are direct and specific antagonists of the activity of prostaglandin H.sub.2 and thromboxane A.sub.2.
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