US Patent No: 4,244,787

Number of patents in Portfolio can not be more than 2000

Apparatus and method for determining serum concentrates of metabolites by monitoring dialysate fluid

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Abstract

An apparatus and method are disclosed for monitoring, analyzing and quantitating in real time the concentrations of metabolites in serum by analyzing the dialysate solutions which are being equilibrated with the blood via a hemodialyzer. Thus, access to certain metabolically important species is provided without the necessity of blood sampling. The apparatus includes at least one ion-selective electrode coupled with the dialysate effluent stream, and the electrode EMF is converted to dialysate concentrations based on precalibration. The dialysate concentrations, in turn, are related to serum levels by factors governing mass transfer through the dialyzer.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH, EDUCATION & WELFAREWASHINGTON, DC1

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Klein, Elias Louisville, KY 17 218
Wathen, Ronald L Louisville, KY 13 187

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Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
BAXTER INTERNATIONAL INC. (9)
5,518,623 Hemodialysis monitoring system for hemodialysis machines 69 1994
5,507,723 Method and system for optimizing dialysis clearance 67 1994
5,442,969 Fluid sampling module 29 1994
5,873,853 Portable pump apparatus for continuous ambulatory peritoneal dialysis and a method for providing same 22 1995
5,662,806 Hemodialysis monitoring system for hemodialysis machines 28 1996
5,849,179 Automatic apparatus for obtaining equilibration samples of dialysate 7 1996
6,196,992 Portable pump apparatus for continuous ambulatory peritoneal dialysis and a method for providing same 66 1997
5,984,891 Portable pump apparatus for continuous ambulatory peritoneal dialysis and a method for providing same 38 1998
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FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH (2)
7,674,235 Method for determining concentration; a dialyser 6 2005
8,361,006 Blood treatment device 0 2010
 
LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (2)
5,698,083 Chemiresistor urea sensor 57 1995
5,858,186 Urea biosensor for hemodialysis monitoring 29 1996
 
CIPOSA MICROTECHNIQUES S.A. (1)
5,404,761 Device for continuously collecting a dialysate sample 2 1993
 
FALKVALL, THORE (1)
6,666,840 Method for determining waste products in the dialysis liquid in dialysis treatment 5 2001
 
GAMBRO HOSPAL (SCHWEIZ) AG (1)
5,954,951 Device for collecting a sample of used dialysis fluid 6 1997
 
RENAL SOLUTIONS, INC. (1)
8,409,864 Ammonia sensor and system for use 0 2006
 
THORN EMI PLC (1)
5,206,145 Method of measuring the concentration of a substance in a sample solution 108 1991