US Patent No: 4,244,787

Number of patents in Portfolio can not be more than 2000

Apparatus and method for determining serum concentrates of metabolites by monitoring dialysate fluid

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Abstract

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An apparatus and method are disclosed for monitoring, analyzing and quantitating in real time the concentrations of metabolites in serum by analyzing the dialysate solutions which are being equilibrated with the blood via a hemodialyzer. Thus, access to certain metabolically important species is provided without the necessity of blood sampling. The apparatus includes at least one ion-selective electrode coupled with the dialysate effluent stream, and the electrode EMF is converted to dialysate concentrations based on precalibration. The dialysate concentrations, in turn, are related to serum levels by factors governing mass transfer through the dialyzer.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH, EDUCATION & WELFAREWASHINGTON, DC0

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Klein, Elias New Orleans, LA 15 301
Wathen, Ronald L Louisville, KY 13 260

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Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
THORN EMI PLC (1)
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FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH (5)
* 2007/0135,750 Blood treatment device 4 2004
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* 2005/0236,330 Method for determining concentration; a dialyser 10 2005
8,361,006 Blood treatment device 0 2010
* 2011/0077,575 Blood treatment device 0 2010
 
FRESENIUS MEDICAL CARE HOLDINGS, INC. (2)
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* 2012/0258,545 MEASURING CHEMICAL PROPERTIES OF A SAMPLE FLUID IN DIALYSIS SYSTEMS 0 2011
 
GAMBRO LUNDIA AB (2)
8,741,147 Control apparatus and control method for a blood treatment equipment 0 2010
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FALKVALL, THORE (1)
6,666,840 Method for determining waste products in the dialysis liquid in dialysis treatment 16 2001
 
DEBIOTECH S.A. (5)
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* 2012/0029,325 Device for determining the characteristics of peritoneal membrane 0 2011
* 9,149,571 Peritoneal dialysis system 0 2012
* 2012/0310,056 Peritoneal dialysis system 0 2012
 
BAXTER INTERNATIONAL INC. (13)
* 5,518,623 Hemodialysis monitoring system for hemodialysis machines 83 1994
* 5,507,723 Method and system for optimizing dialysis clearance 93 1994
* 5,442,969 Fluid sampling module 35 1994
* 5,873,853 Portable pump apparatus for continuous ambulatory peritoneal dialysis and a method for providing same 50 1995
* 5,662,806 Hemodialysis monitoring system for hemodialysis machines 40 1996
* 5,849,179 Automatic apparatus for obtaining equilibration samples of dialysate 9 1996
6,196,992 Portable pump apparatus for continuous ambulatory peritoneal dialysis and a method for providing same 102 1997
* 5,984,891 Portable pump apparatus for continuous ambulatory peritoneal dialysis and a method for providing same 66 1998
* 2003/0216,677 Biosensor for dialysis therapy 23 2002
* 2009/0299,272 DIALYSIS SYSTEM HAVING AUTOMATED EFFLUENT SAMPLING AND PERITONEAL EQUILIBRATION TEST 5 2008
9,147,045 Peritoneal equilibration test and dialysis system using same 0 2008
* 2010/0010,425 PERITONEAL EQUILIBRATION TEST AND DIALYSIS SYSTEM USING SAME 0 2008
8,180,574 Simplified peritoneal equilibration test for peritoneal dialysis 1 2009
 
BAXTER HEALTHCARE S.A. (1)
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Baxter Healthcare Inc. (2)
8,449,495 Dialysis system having automated effluent sampling and peritoneal equilibration test 0 2008
8,926,551 Peritoneal dialysis therapy with large dialysis solution volumes 0 2009
 
HOSPAL INTERNATIONAL MARKETING MANAGEMENT (2)
8,512,564 Control apparatus and control method for a blood treatment equipment 0 2003
* 2006/0157,413 Control apparatus and control method for a blood treatment equipment 8 2003
 
Renal Solutions, Inc. (2)
8,409,864 Ammonia sensor and system for use 1 2006
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LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (2)
* 5,698,083 Chemiresistor urea sensor 105 1995
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Nova Biomedical Corporation (2)
8,617,366 Disposable urea sensor and system for determining creatinine and urea nitrogen-to-creatinine ratio in a single device 1 2005
* 2007/0131,548 DISPOSABLE UREA SENSOR AND SYSTEM FOR DETERMINING CREATININE AND UREA NITROGEN-TO-CREATININE RATIO IN A SINGLE DEVICE 3 2005
 
CIPOSA MICROTECHNIQUES S.A. (1)
* 5,404,761 Device for continuously collecting a dialysate sample 2 1993
* Cited By Examiner