US Patent No: 4,244,787

Number of patents in Portfolio can not be more than 2000

Apparatus and method for determining serum concentrates of metabolites by monitoring dialysate fluid

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Abstract

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An apparatus and method are disclosed for monitoring, analyzing and quantitating in real time the concentrations of metabolites in serum by analyzing the dialysate solutions which are being equilibrated with the blood via a hemodialyzer. Thus, access to certain metabolically important species is provided without the necessity of blood sampling. The apparatus includes at least one ion-selective electrode coupled with the dialysate effluent stream, and the electrode EMF is converted to dialysate concentrations based on precalibration. The dialysate concentrations, in turn, are related to serum levels by factors governing mass transfer through the dialyzer.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH, EDUCATION & WELFAREWASHINGTON, DC4

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Klein, Elias Louisville, KY 19 242
Wathen, Ronald L Louisville, KY 13 213

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Patent Info (Count) # Cites Year
 
BAXTER INTERNATIONAL INC. (9)
5,518,623 Hemodialysis monitoring system for hemodialysis machines 76 1994
5,507,723 Method and system for optimizing dialysis clearance 78 1994
5,442,969 Fluid sampling module 30 1994
5,873,853 Portable pump apparatus for continuous ambulatory peritoneal dialysis and a method for providing same 30 1995
5,662,806 Hemodialysis monitoring system for hemodialysis machines 33 1996
5,849,179 Automatic apparatus for obtaining equilibration samples of dialysate 7 1996
6,196,992 Portable pump apparatus for continuous ambulatory peritoneal dialysis and a method for providing same 79 1997
5,984,891 Portable pump apparatus for continuous ambulatory peritoneal dialysis and a method for providing same 48 1998
8,180,574 Simplified peritoneal equilibration test for peritoneal dialysis 0 2009
 
FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH (2)
7,674,235 Method for determining concentration; a dialyser 6 2005
8,361,006 Blood treatment device 0 2010
 
LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (2)
5,698,083 Chemiresistor urea sensor 73 1995
5,858,186 Urea biosensor for hemodialysis monitoring 38 1996
 
Baxter Healthcare Inc. (1)
8,449,495 Dialysis system having automated effluent sampling and peritoneal equilibration test 0 2008
 
CIPOSA MICROTECHNIQUES S.A. (1)
5,404,761 Device for continuously collecting a dialysate sample 2 1993
 
FALKVALL, THORE (1)
6,666,840 Method for determining waste products in the dialysis liquid in dialysis treatment 7 2001
 
GAMBRO HOSPAL (SCHWEIZ) AG (1)
5,954,951 Device for collecting a sample of used dialysis fluid 10 1997
 
GAMBRO LUNDIA AB (1)
8,741,147 Control apparatus and control method for a blood treatment equipment 0 2010
 
HOSPAL INTERNATIONAL MARKETING MANAGEMENT (1)
8,512,564 Control apparatus and control method for a blood treatment equipment 0 2003
 
NOVA BIOMEDICAL CORPORATION (1)
8,617,366 Disposable urea sensor and system for determining creatinine and urea nitrogen-to-creatinine ratio in a single device 0 2005
 
RENAL SOLUTIONS, INC. (1)
8,409,864 Ammonia sensor and system for use 0 2006
 
THORN EMI PLC (1)
5,206,145 Method of measuring the concentration of a substance in a sample solution 152 1991

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