Apparatus and method for determining serum concentrates of metabolites by monitoring dialysate fluid

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United States of America Patent

PATENT NO

4244787

SERIAL NO

06047786

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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An apparatus and method are disclosed for monitoring, analyzing and quantitating in real time the concentrations of metabolites in serum by analyzing the dialysate solutions which are being equilibrated with the blood via a hemodialyzer. Thus, access to certain metabolically important species is provided without the necessity of blood sampling. The apparatus includes at least one ion-selective electrode coupled with the dialysate effluent stream, and the electrode EMF is converted to dialysate concentrations based on precalibration. The dialysate concentrations, in turn, are related to serum levels by factors governing mass transfer through the dialyzer.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH, EDUCATION & WELFAREWASHINGTON, DC0

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Klein, Elias New Orleans, LA 15 311
Wathen, Ronald L Louisville, KY 13 266

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Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
THORN EMI PLC (1)
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FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH (5)
* 2007/0135,750 Blood treatment device 4 2004
* 7674235 Method for determining concentration; a dialyser 9 2005
* 2005/0236,330 Method for determining concentration; a dialyser 14 2005
8361006 Blood treatment device 0 2010
* 2011/0077,575 Blood treatment device 0 2010
 
FRESENIUS MEDICAL CARE HOLDINGS, INC. (2)
* 8945936 Measuring chemical properties of a sample fluid in dialysis systems 0 2011
* 2012/0258,545 MEASURING CHEMICAL PROPERTIES OF A SAMPLE FLUID IN DIALYSIS SYSTEMS 2 2011
 
GAMBRO LUNDIA AB (2)
8741147 Control apparatus and control method for a blood treatment equipment 0 2010
* 2010/0219,129 CONTROL APPARATUS AND CONTROL METHOD FOR A BLOOD TREATMENT EQUIPMENT 1 2010
 
FALKVALL, THORE (1)
6666840 Method for determining waste products in the dialysis liquid in dialysis treatment 18 2001
 
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* 2005/0089,994 Peritoneal dialysis system 12 2004
* 9125989 Device for determining the characteristics of peritoneal membrane 0 2011
* 2012/0029,325 Device for determining the characteristics of peritoneal membrane 0 2011
* 9149571 Peritoneal dialysis system 0 2012
* 2012/0310,056 Peritoneal dialysis system 0 2012
 
BAXTER INTERNATIONAL INC. (13)
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* 5507723 Method and system for optimizing dialysis clearance 95 1994
* 5442969 Fluid sampling module 35 1994
* 5873853 Portable pump apparatus for continuous ambulatory peritoneal dialysis and a method for providing same 54 1995
* 5662806 Hemodialysis monitoring system for hemodialysis machines 41 1996
* 5849179 Automatic apparatus for obtaining equilibration samples of dialysate 9 1996
6196992 Portable pump apparatus for continuous ambulatory peritoneal dialysis and a method for providing same 105 1997
* 5984891 Portable pump apparatus for continuous ambulatory peritoneal dialysis and a method for providing same 69 1998
* 2003/0216,677 Biosensor for dialysis therapy 26 2002
* 2009/0299,272 DIALYSIS SYSTEM HAVING AUTOMATED EFFLUENT SAMPLING AND PERITONEAL EQUILIBRATION TEST 6 2008
9147045 Peritoneal equilibration test and dialysis system using same 0 2008
* 2010/0010,425 PERITONEAL EQUILIBRATION TEST AND DIALYSIS SYSTEM USING SAME 1 2008
8180574 Simplified peritoneal equilibration test for peritoneal dialysis 1 2009
 
BAXTER HEALTHCARE S.A. (1)
* 5954951 Device for collecting a sample of used dialysis fluid 15 1997
 
Baxter Healthcare Inc. (2)
8449495 Dialysis system having automated effluent sampling and peritoneal equilibration test 0 2008
8926551 Peritoneal dialysis therapy with large dialysis solution volumes 0 2009
 
HOSPAL INTERNATIONAL MARKETING MANAGEMENT (2)
8512564 Control apparatus and control method for a blood treatment equipment 0 2003
* 2006/0157,413 Control apparatus and control method for a blood treatment equipment 10 2003
 
Renal Solutions, Inc. (2)
8409864 Ammonia sensor and system for use 3 2006
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LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (2)
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* 5858186 Urea biosensor for hemodialysis monitoring 59 1996
 
NOVA BIOMEDICAL CORPORATION (2)
8617366 Disposable urea sensor and system for determining creatinine and urea nitrogen-to-creatinine ratio in a single device 1 2005
* 2007/0131,548 DISPOSABLE UREA SENSOR AND SYSTEM FOR DETERMINING CREATININE AND UREA NITROGEN-TO-CREATININE RATIO IN A SINGLE DEVICE 6 2005
 
Ciposa Microtechniques S.A. (1)
* 5404761 Device for continuously collecting a dialysate sample 2 1993
* Cited By Examiner