Peptides related to somatostatin
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United States of America Patent
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Mar 3, 1981
Issued Date -
N/A
app pub date -
Mar 9, 1979
filing date -
Mar 9, 1979
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Peptides of the formula: ##STR1## wherein: X is H, --NH.sub.2, --NH--Gly--Ala, --NH--D--Ala--Ala, --NH--Gly--Gly--Gly, --NH--acetyl, or --NH--benzoyl; X.sub.1 is His or Arg; X.sub.2 is His, Glu, Tyr, Trp, or Phe; X.sub.3 is Trp, D-Trp, or 6-F-D-Trp; and X.sub.4 is a D-.alpha.-amino acid; or the reduced, linear form thereof, or a non-toxic, pharmaceutically acceptable acid addition salt thereof; inhibit the release of growth hormone, insulin, and glucagon; and show prolonged inhibition activity. Said peptides are prepared by solid-state methodology.
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