Method and composition for the preparation of controlled long-acting pharmaceuticals

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO

4259314

SERIAL NO

06102227

1 Status Updates

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

A method and composition for the preparation of controlled long-acting pharmaceuticals using a dry carrier or base material comprising an effective amount of hydroxypropyl methylcellulose and hydroxypropyl cellulose suitable for use with both hygroscopic and non-hygroscopic materials. The controlled long-acting products of the invention are suitable for use in the form of lozenges, buccal tablets, oral tablets or suppositories.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

  • Assignment data not available. Check PTO

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lowey, Hans 7 Deerfield La., Mamaroneck, NY 10543 4 194

Cited Art Landscape

  • No Cited Art to Display

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
RECKITT BENCKISER LLC (12)
6372252 Guaifenesin sustained release formulation and tablets 17 2000
6955821 Sustained release formulations of guaifenesin and additional drug ingredients 13 2002
* 2003/0049,318 Sustained release formulations of guaifenesin and additional drug ingredients 14 2002
7985420 Sustained release of guaifenesin combination drugs 0 2003
7838032 Sustained release of guaifenesin 2 2003
* 2004/0022,851 Sustained release of guaifenesin combination drugs 6 2003
* 2004/0018,233 Sustained release of guaifenesin 5 2003
8012504 Sustained release of guaifenesin combination drugs 1 2003
* 2003/0215,508 Sustained release of guaifenesin combination drugs 7 2003
7985421 Sustained release formulations of guaifenesin and additional drug ingredients 0 2005
* 2005/0276,852 Sustained release formulations of guaifenesin and additional drug ingredients 20 2005
* 2011/0052,689 SUSTAINED RELEASE OF GUAIFENESIN 0 2010
 
Other [Check patent profile for assignment information] (13)
* 4680323 Method and composition for the preparation of controlled long-acting pharmaceuticals for oral administration 37 1983
* 4775535 Method of preparing controlled long-acting pharmaceutical formulations in unit dosage form having uniform and comparable bioavailability characteristics 22 1986
* 4855143 Method of preparing controlled long-acting pharmaceutical formulations in unit dosage form having uniform and comparable bioavailability characteristics 22 1988
6264974 Buccal and sublingual administration of physostigmine 6 1998
* 2003/0171,419 Pharmaceutical compositions comprising fluvastatin 0 2002
* 2004/0096,500 Controlled release oxycodone compositions 37 2003
* 2004/0185,098 Controlled release oxycodone compositions 24 2004
* 2006/0057,165 Clostridium botulinum toxin formulation and method for reducing weight 11 2005
* 2006/0099,263 Antidepressant dosage form 0 2005
* 2006/0127,474 Pharmaceutical compositions comprising fluvastatin 0 2006
* 2007/0225,341 Nicotinic Acid Compositions For Treating Hyperlipidemia and Related Methods Therefor 1 2007
* 2007/0225,342 Nicotinic Acid Compositions For Treating Hyperlipidemia and Related Methods Therefor 0 2007
* 2010/0311,802 SUSTAINED RELEASE PHARMACEUTICAL COMPOSITION AND METHOD OF RELEASING PHARMACEUTICALLY ACTIVE AGENT 0 2010
 
Unitel Technologies, Inc. (3)
6821532 Methods and compositions for the treatment of benign prostatic hypertrophy 2 2001
6733796 Methods and compositions for the treatment of benign prostatic hypertrophy 3 2002
* 2003/0096,009 Methods and compositions for the treatment of benign prostatic hypertrophy 0 2002
 
ELAN CORPORATION, PLC (1)
* 6110494 Cisapride mini-tablet formulations 8 1997
 
CHRISTIAN HANSEN A/S (2)
* 5645830 Lactobacillus and skim milk compositions and methods for preventing microbial urogenital infections 17 1994
* 6004551 Lactobacillus and skim milk pharmaceutical compositions 12 1996
 
NOVARTIS AG (4)
6242003 Organic compounds 4 2000
6432447 Organic compounds 1 2001
8303987 Pharmaceutical compositions comprising fluvastatin 0 2010
* 2010/0303,919 PHARMACEUTICAL COMPOSITIONS COMPRISING FLUVASTATIN 0 2010
 
JASON ENTERPRISES, INC. (1)
* 2003/0167,556 Methods and devices for transdermal delivery of anti-aging compounds for treatment and prevention of facial or neck skin aging 22 2002
 
BIONEVIA PHARMACEUTICALS, INC. (1)
9566269 Modified release compositions of epalrestat or a derivative thereof and methods for using the same 0 2012
 
PALMETTO PHARMACEUTICALS, LLC (6)
* 2011/0196,039 Controlled release arginine formulations 0 2001
7381731 Pharmaceutical composition comprising citrulline 0 2004
* 2004/0242,682 Compositions comprising arginine and nitrates 1 2004
* 2004/0186,164 Pharmaceutical composition comprising citrulline 0 2004
* 2005/0085,548 Method and formulation for treating vascular disease 0 2004
* 2011/0212,174 CONTROLLED RELEASE ARGININE FORMULATIONS 0 2011
 
FUJISAWA PHARMACEUTICAL CO., LTD. (1)
* 4654206 Fast release solid preparation of dihydropyridine a compound 14 1984
 
KOS LIFE SCIENCES, INC. (1)
7998506 Nicotinic acid compositions for treating hyperlipidemia and related methods therefor 0 2003
 
ACTAVIS GROUP HF (1)
* 2004/0086,566 Waxy matrix dosage forms 1 2002
 
HOFFMANN-LA ROCHE INC. (1)
* 5393765 Pharmaceutical compositions with constant erosion volume for zero order controlled release 36 1993
 
KOS LIFE SCIENCES LLC (2)
* 6080428 Nicotinic acid compositions for treating hyperlipidemia and related methods therefor 5 1995
* 6129930 Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night 11 1997
 
EFFCON LABORATORIES, INC. (1)
6214381 Methazolamide composition and method of use 0 1998
 
ABBOTT RESPIRATORY LLC (3)
6818229 Intermediate release nicotinic acid compositions for treating hyperlipidemia 10 1997
6746691 Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics 9 1997
6676967 Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia 9 1997
 
ASTELLAS PHARMA INC. (1)
* 4916138 Solid dispersion composition of FR-900506 substance 59 1988
 
NIPPON SODA CO., LTD. (1)
8617596 Sustained-release tablet production process 0 2007
 
THERACOS, INC. (1)
* 2005/0143,350 Combination drug therapy to treat obesity 3 2004
 
Plastic Dress-Up Co. (1)
* 5895663 Pseudoephedrine hydrochloride extended-release tablets 33 1997
 
FARVALSA A.G. (1)
* 4837032 Theophylline sustained release tablet 18 1986
 
HANALL BIOPHARMA CO., LTD. (1)
* 2011/0038,931 COMPOSITE PREPARATION 0 2009
 
GLOBALFOUNDRIES INC. (1)
* 2008/0055,036 Electrical component tuned by conductive layer deletion 1 2006
 
Anestic ApS (1)
* 2004/0047,910 Suppository and composition comprising at least one polyethylene glycol 13 2003
 
SHIONOGI INC. (4)
* 2009/0087,490 EXTENDED RELEASE FORMULATION AND METHOD OF TREATING ADRENERGIC DYSREGULATION 1 2008
* 2010/0209,510 Extended Release Formulation and Method of Treating Adrenergic Dysregulation 0 2009
7884122 Extended release formulation and method of treating adrenergic dysregulation 1 2009
* 2010/0172,991 Extended Release Formulation and Methods of Treating Adrenergic Dysregulation 0 2009
 
FOREST LABORATORIES, INC. (6)
* 4369172 Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose 241 1981
* 4389393 Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose 309 1982
* 4795327 Controlled release solid drug dosage forms based on mixtures of water soluble nonionic cellulose ethers and anionic surfactants 44 1984
* 4540566 Prolonged release drug dosage forms based on modified low viscosity grade hydroxypropylmethylcellulose 72 1984
* 4849229 Controlled release solid drug dosage forms based on mixtures of water soluble nonionic cellulose ethers and anionic surfactants 30 1988
* 4983398 Sustained release drug dosage forms containing hydroxypropylmethylcellulose and alkali metal carboxylates 31 1988
 
SANDOZ LTD. (1)
* 5069911 Pharmaceutical 9,10-dihydrogenated ergot alkaloid containing compositions 5 1990
 
FABRE-KRAMER PHARMACEUTICALS, INC. (1)
* 2006/0134,193 Method to improve pharmaceutical tablets having a matrix of cellulose ether 0 2003
 
NASTECH PHARMACEUTICAL COMPANY INC. (4)
* 2005/0143,303 Intranasal administration of glucose-regulating peptides 24 2004
* 2008/0318,837 Pharmaceutical Formation For Increased Epithelial Permeability of Glucose-Regulating Peptide 31 2006
* 2008/0318,861 Mucosal Delivery of Stabilized Formulations of Exendin 0 2006
* 2008/0234,200 METHOD OF TREATMENT OF A METABOLIC DISEASE USING INTRANASAL ADMINISTRATION OF EXENDIN PEPTIDE 4 2008
 
RANBAXY LABORATORIES LIMITED (2)
6960356 Orally administered drug delivery system providing temporal and spatial control 10 1999
* 2006/0147,530 Sustained release compositions containing alfuzosin 1 2003
 
CONCORDIA PHARMACEUTICALS, INC. (3)
* 5484607 Extended release clonidine formulation 35 1993
* 5869100 Extended release clonidine formulation (tablet) 25 1997
* 6030642 Extended release clonidine formulation (capsule) 24 1997
 
RANBAXY RESEARCH LABORATORIES (1)
* 5948440 Modified release matrix formulation of cefaclor and cephalexin 14 1997
 
Key Pharmaceuticals, Inc. (3)
* 4508702 Sustained release aspirin 11 1984
* 4555399 Aspirin tablet 41 1984
* 4634587 Sustained release quinidine dosage form 22 1984
 
BIOVASCULAR, INC. (3)
* 2009/0324,710 Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor 8 2009
9040483 Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor 1 2012
9381198 Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor 0 2015
 
VALEANT INTERNATIONAL BERMUDA (1)
6893661 Controlled release formulations using intelligent polymers 21 1998
 
ALZA CORPORATION (5)
* 4786503 Dosage form comprising parallel lamine 36 1987
* 4851232 Drug delivery system with means for obtaining desirable in vivo release rate pattern 51 1987
* 4946685 Cellulosic dosage form 59 1988
* 5204116 Dosage form providing immediate therapy followed by prolonged therapy 23 1991
* 5338550 Stereoisomer therapy 8 1992
 
PENWEST PHARMACEUTICALS CO. (7)
* 4994276 Directly compressible sustained release excipient 71 1988
* 5128143 Sustained release excipient and tablet formulation 65 1990
* 5135757 Compressible sustained release solid dosage forms 47 1991
* 5169639 Controlled release verapamil tablets 34 1991
* 5472711 Agglomerated hydrophilic complexes with multi-phasic release characteristics 44 1992
* 5478574 Agglomerated hydrophilic complexes with multi-phasic release characteristics 28 1993
* 5670168 Agglomerated hydrophilic complexes with multi-phasic release characteristics 29 1996
 
EURO-CELTIQUE S.A. (9)
* 4366310 Controlled release compositions 88 1980
* 5891471 Pharmaceutical multiparticulates 157 1996
* 5849240 Method of preparing sustained release pharmaceutical compositions 178 1996
* 5843480 Controlled release diamorphine formulation 127 1996
* 6068855 Pharmaceutical composition containing a fusible carrier and method for producing the same 93 1997
* 5965163 Substained release compositions and a method of preparing pharmaceutical compositions 168 1997
* 6162467 Sustained release compositions and a method of preparing pharmaceutical compositions 135 1999
8557286 Method for producing a water-insoluble amorphous or partially amorphous controlled release matrix 0 2000
* 2004/0170,680 Once-a-day oxycodone formulations 99 2004
 
SCHERING CORPORATION (3)
* 4601894 Controlled release dosage form comprising acetaminophen, pseudoephedrine sulfate and dexbrompheniramine maleate 31 1985
* 4695591 Controlled release dosage forms comprising hydroxypropylmethylcellulose 49 1985
* 4657757 Controlled release dosage form comprising acetaminophen, pseudoephedrine sulfate and dexbrompheniramine maleate 14 1985
 
PURDUE PHARMA L.P. (10)
* 5965161 Extruded multi-particulates 194 1994
* 5958452 Extruded orally administrable opioid formulations 229 1997
6335033 Melt-extrusion multiparticulates 133 1999
6261599 Melt-extruded orally administrable opioid formulations 181 1999
6743442 Melt-extruded orally administrable opioid formulations 86 2001
6706281 Melt-extrusion multiparticulates 92 2002
* 2005/0089,568 Melt-extruded orally administrable opioid formulations 37 2003
7510727 Melt-extrusion multiparticulates 8 2003
* 2010/0092,570 CONTROLLED RELEASE OXYCODONE COMPOSITIONS 13 2009
* 2010/0034,876 CONTROLLED RELEASE OXYCODONE COMPOSITIONS 13 2009
 
THE DOW CHEMICAL COMPANY (3)
* 4695464 Sustained release dosage form based on highly plasticized cellulose ether gels 31 1984
* 4678516 Sustained release dosage form based on highly plasticized cellulose ether gels 63 1984
* 4734285 Sustained release compositions 39 1985
 
Aktiebolaget Hassle (1)
* 4942040 Pharmaceutical preparation and a process for its preparation 39 1988
 
DRUGTECH CORPORATION (1)
* 5445829 Extended release pharmaceutical formulations 206 1992
 
Temple University (1)
6337091 Matrix for controlled delivery of highly soluble pharmaceutical agents 16 1997
 
AlphaRx, Inc. (1)
* 2005/0037,073 Solid self-emulsifying dosage form for improved delivery of poorly soluble hydrophobic compounds and the process for preparation thereof 5 2004
 
E. R. Squibb & Sons, Inc. (4)
* 4505890 Controlled release formulation and method 23 1983
* 4610870 Controlled release formulation 106 1984
* 4666705 Controlled release formulation 74 1985
* 4756911 Controlled release formulation 99 1986
 
SUPERNUS PHARMACEUTICALS, INC. (2)
8709476 Compositions of quaternary ammonium compounds containing bioavailability enhancers 0 2004
* 2006/0210,625 Sustained release of positively charged pharmacologically active molecules from a matrix containing polymers with polarized oxygen atoms 4 2004
 
Mead Johnson & Company (2)
* 4465660 Sustained release tablet containing at least 95 percent theophylline 28 1982
* 4547358 Sustained release tablet containing at least 95 percent theophylline 14 1984
 
NAPP PHARMACEUTICAL GROUP LIMITED (5)
* 5591452 Controlled release formulation 106 1994
6326027 Controlled release formulation 101 1995
6254887 Controlled release tramadol 106 1996
7074430 Controlled release tramadol tramadol formulation 34 2001
* 2006/0269,603 Controlled release tramadol formulations 29 2006
 
Nostrum Pharmaceuticals, Inc. (1)
7179486 Process for preparing sustained release tablets 9 2001
 
PURDUE PHARMA COMPANY, THE (2)
* 2006/0057,210 Controlled release oxycodone compositions 17 2005
* 2008/0075,781 Controlled release oxycodone compositions 13 2007
 
SYNGENTA LIMITED (1)
* 5948437 Pharmaceutical compositions using thiazepine 23 1997
 
TCD ROYALTY SUB, LLC (7)
7781448 Once daily dosage forms of trospium 0 2007
7781449 Trospium chloride treatment method 0 2007
7763635 Once daily dosage forms of trospium 8 2007
7759359 Method of treating bladder dysfunction with once-a-day trospium salt formulation 0 2007
* 2010/0221,355 PHARMACEUTICAL COMPOSITION FOR ONCE-A-DAY ORAL ADMINISTRATION OF TROSPIUM CHLORIDE 0 2010
* 2010/0221,353 Pharmaceutical Composition For Once-A-Day Administration of Trospium Chloride 0 2010
* 2010/0222,375 Pharmaceutical Composition Comprising Trospium Chloride for Once-A-Day Administration 0 2010
 
SHIN-ETSU CHEMICAL CO., LTD. (1)
* 5476668 Base for film-coating pharmaceuticals and method for preparing same 6 1993
 
Societe Civile dite: "Medibrevex" (1)
* 5061493 Galenical forms of corticoids for administration perlingually and sublingually and process for their preparation 2 1988
 
HERCULES INCORPORATED (2)
* 5480984 Process of preparing high solids low viscosity polysaccharides 11 1992
6210710 Sustained release polymer blend for pharmaceutical applications 49 1997
 
LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d. (1)
* 6042847 Three-phase pharmaceutical form with constant and controlled release of amorphous active ingredient for single daily application 51 1997
 
TAYLOR MADE GOLF COMPANY, INC. (1)
* 2008/0102,982 Golf club iron head 18 2007
 
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (1)
* 5840756 Pharmaceutical composition of L-DOPA ester 27 1996
 
TCF NATIONAL BANK (2)
* 5126145 Controlled release tablet containing water soluble medicament 129 1990
* 5268181 Method of using niacin to control nocturnal cholesterol synthesis 19 1992
* Cited By Examiner