US Patent No: 4,259,314

Number of patents in Portfolio can not be more than 2000

Method and composition for the preparation of controlled long-acting pharmaceuticals

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Abstract

A method and composition for the preparation of controlled long-acting pharmaceuticals using a dry carrier or base material comprising an effective amount of hydroxypropyl methylcellulose and hydroxypropyl cellulose suitable for use with both hygroscopic and non-hygroscopic materials. The controlled long-acting products of the invention are suitable for use in the form of lozenges, buccal tablets, oral tablets or suppositories.

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First Claim

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  • Assignment data not available. Check USPTO

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lowey, Hans 1045 Nine Acres La., Mamaroneck, NY 10541 4 183

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Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
EURO-CELTIQUE S.A. (7)
4,366,310 Controlled release compositions 27 1980
5,891,471 Pharmaceutical multiparticulates 50 1996
5,849,240 Method of preparing sustained release pharmaceutical compositions 59 1996
5,843,480 Controlled release diamorphine formulation 41 1996
6,068,855 Pharmaceutical composition containing a fusible carrier and method for producing the same 38 1997
5,965,163 Substained release compositions and a method of preparing pharmaceutical compositions 58 1997
6,162,467 Sustained release compositions and a method of preparing pharmaceutical compositions 41 1999
 
PENWEST PHARMACEUTICALS CO. (7)
4,994,276 Directly compressible sustained release excipient 69 1988
5,128,143 Sustained release excipient and tablet formulation 63 1990
5,135,757 Compressible sustained release solid dosage forms 43 1991
5,169,639 Controlled release verapamil tablets 33 1991
5,472,711 Agglomerated hydrophilic complexes with multi-phasic release characteristics 31 1992
5,478,574 Agglomerated hydrophilic complexes with multi-phasic release characteristics 27 1993
5,670,168 Agglomerated hydrophilic complexes with multi-phasic release characteristics 22 1996
 
PURDUE PHARMA L.P. (7)
5,965,161 Extruded multi-particulates 60 1994
5,958,452 Extruded orally administrable opioid formulations 76 1997
6,335,033 Melt-extrusion multiparticulates 40 1999
6,261,599 Melt-extruded orally administrable opioid formulations 63 1999
6,743,442 Melt-extruded orally administrable opioid formulations 16 2001
6,706,281 Melt-extrusion multiparticulates 15 2002
7,510,727 Melt-extrusion multiparticulates 0 2003
 
FOREST LABORATORIES, INC. (6)
4,369,172 Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose 210 1981
4,389,393 Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose 206 1982
4,795,327 Controlled release solid drug dosage forms based on mixtures of water soluble nonionic cellulose ethers and anionic surfactants 31 1984
4,540,566 Prolonged release drug dosage forms based on modified low viscosity grade hydroxypropylmethylcellulose 64 1984
4,849,229 Controlled release solid drug dosage forms based on mixtures of water soluble nonionic cellulose ethers and anionic surfactants 27 1988
4,983,398 Sustained release drug dosage forms containing hydroxypropylmethylcellulose and alkali metal carboxylates 23 1988
 
RECKITT BENCKISER LLC (6)
6,372,252 Guaifenesin sustained release formulation and tablets 9 2000
6,955,821 Sustained release formulations of guaifenesin and additional drug ingredients 4 2002
7,985,420 Sustained release of guaifenesin combination drugs 0 2003
7,838,032 Sustained release of guaifenesin 0 2003
8,012,504 Sustained release of guaifenesin combination drugs 1 2003
7,985,421 Sustained release formulations of guaifenesin and additional drug ingredients 0 2005
 
ALZA CORPORATION (5)
4,786,503 Dosage form comprising parallel lamine 30 1987
4,851,232 Drug delivery system with means for obtaining desirable in vivo release rate pattern 36 1987
4,946,685 Cellulosic dosage form 56 1988
5,204,116 Dosage form providing immediate therapy followed by prolonged therapy 18 1991
5,338,550 Stereoisomer therapy 7 1992
 
E. R. SQUIBB & SONS, INC. (4)
4,505,890 Controlled release formulation and method 22 1983
4,610,870 Controlled release formulation 71 1984
4,666,705 Controlled release formulation 40 1985
4,756,911 Controlled release formulation 74 1986
 
NAPP PHARMACEUTICAL GROUP LIMITED (4)
5,591,452 Controlled release formulation 50 1994
6,326,027 Controlled release formulation 37 1995
6,254,887 Controlled release tramadol 35 1996
7,074,430 Controlled release tramadol tramadol formulation 9 2001
 
SHIONOGI INC. (4)
5,484,607 Extended release clonidine formulation 7 1993
5,869,100 Extended release clonidine formulation (tablet) 3 1997
6,030,642 Extended release clonidine formulation (capsule) 3 1997
7,884,122 Extended release formulation and method of treating adrenergic dysregulation 0 2009
 
SUPERNUS PHARMACEUTICALS, INC (4)
7,781,448 Once daily dosage forms of trospium 0 2007
7,781,449 Trospium chloride treatment method 0 2007
7,763,635 Once daily dosage forms of trospium 2 2007
7,759,359 Method of treating bladder dysfunction with once-a-day trospium salt formulation 0 2007
 
ABBOTT RESPIRATORY LLC (3)
6,818,229 Intermediate release nicotinic acid compositions for treating hyperlipidemia 4 1997
6,746,691 Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics 4 1997
6,676,967 Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia 4 1997
 
KEY PHARMACEUTICALS, INC. (3)
4,508,702 Sustained release aspirin 11 1984
4,555,399 Aspirin tablet 38 1984
4,634,587 Sustained release quinidine dosage form 18 1984
 
NOVARTIS AG (3)
6,242,003 Organic compounds 4 2000
6,432,447 Organic compounds 1 2001
8,303,987 Pharmaceutical compositions comprising fluvastatin 0 2010
 
SCHERING CORPORATION (3)
4,601,894 Controlled release dosage form comprising acetaminophen, pseudoephedrine sulfate and dexbrompheniramine maleate 20 1985
4,695,591 Controlled release dosage forms comprising hydroxypropylmethylcellulose 40 1985
4,657,757 Controlled release dosage form comprising acetaminophen, pseudoephedrine sulfate and dexbrompheniramine maleate 14 1985
 
THE DOW CHEMICAL COMPANY (3)
4,695,464 Sustained release dosage form based on highly plasticized cellulose ether gels 26 1984
4,678,516 Sustained release dosage form based on highly plasticized cellulose ether gels 56 1984
4,734,285 Sustained release compositions 36 1985
 
CHRISTIAN HANSEN A/S (2)
5,645,830 Lactobacillus and skim milk compositions and methods for preventing microbial urogenital infections 11 1994
6,004,551 Lactobacillus and skim milk pharmaceutical compositions 8 1996
 
HERCULES INCORPORATED (2)
5,480,984 Process of preparing high solids low viscosity polysaccharides 6 1992
6,210,710 Sustained release polymer blend for pharmaceutical applications 26 1997
 
KOS LIFE SCIENCES LLC (2)
6,080,428 Nicotinic acid compositions for treating hyperlipidemia and related methods therefor 3 1995
6,129,930 Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night 6 1997
 
MEAD JOHNSON & COMPANY (2)
4,465,660 Sustained release tablet containing at least 95 percent theophylline 22 1982
4,547,358 Sustained release tablet containing at least 95 percent theophylline 9 1984
 
TCF BANK SAVINGS FSB N/K/A TCF NATIONAL BANK (2)
5,126,145 Controlled release tablet containing water soluble medicament 96 1990
5,268,181 Method of using niacin to control nocturnal cholesterol synthesis 17 1992
 
UNITEL TECHNOLOGIES, INC. (2)
6,821,532 Methods and compositions for the treatment of benign prostatic hypertrophy 2 2001
6,733,796 Methods and compositions for the treatment of benign prostatic hypertrophy 3 2002
 
AKTIEBOLAGET HASSLE (1)
4,942,040 Pharmaceutical preparation and a process for its preparation 37 1988
 
ASTELLAS PHARMA INC. (1)
4,916,138 Solid dispersion composition of FR-900506 substance 45 1988
 
DRUGTECH CORPORATION (1)
5,445,829 Extended release pharmaceutical formulations 126 1992
 
EFFCON LABORATORIES, INC. (1)
6,214,381 Methazolamide composition and method of use 0 1998
 
ELAN CORPORATION, PLC (1)
6,110,494 Cisapride mini-tablet formulations 3 1997
 
FARVALSA A.G. (1)
4,837,032 Theophylline sustained release tablet 18 1986
 
FUJISAWA PHARMACEUTICAL CO., LTD. (1)
4,654,206 Fast release solid preparation of dihydropyridine a compound 13 1984
 
HOFFMANN-LA ROCHE INC. (1)
5,393,765 Pharmaceutical compositions with constant erosion volume for zero order controlled release 29 1993
 
KOS LIFE SCIENCES, INC. (1)
7,998,506 Nicotinic acid compositions for treating hyperlipidemia and related methods therefor 0 2003
 
LEK, TOVARNA FARMACEVTSKIH IN KEMICNIH IZDELKOV, D.D. (1)
6,042,847 Three-phase pharmaceutical form with constant and controlled release of amorphous active ingredient for single daily application 21 1997
 
NOSTRUM PHARMACEUTICALS, INC. (1)
7,179,486 Process for preparing sustained release tablets 3 2001
 
PALMETTO PHARMACEUTICALS, LLC (1)
7,381,731 Pharmaceutical composition comprising citrulline 0 2004
 
PLASTIC DRESS-UP CO. (1)
5,895,663 Pseudoephedrine hydrochloride extended-release tablets 12 1997
 
RANBAXY LABORATORIES LIMITED (1)
6,960,356 Orally administered drug delivery system providing temporal and spatial control 5 1999
 
RANBAXY RESEARCH LABORATORIES (1)
5,948,440 Modified release matrix formulation of cefaclor and cephalexin 8 1997
 
SANDOZ LTD. (1)
5,069,911 Pharmaceutical 9,10-dihydrogenated ergot alkaloid containing compositions 3 1990
 
SHIN-ETSU CHEMICAL CO., LTD. (1)
5,476,668 Base for film-coating pharmaceuticals and method for preparing same 4 1993
 
SOCIETE CIVILE DITE: "MEDIBREVEX" (1)
5,061,493 Galenical forms of corticoids for administration perlingually and sublingually and process for their preparation 1 1988
 
SYNGENTA LIMITED (1)
5,948,437 Pharmaceutical compositions using thiazepine 13 1997
 
TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (1)
6,337,091 Matrix for controlled delivery of highly soluble pharmaceutical agents 12 1997
 
VALEANT INTERNATIONAL BERMUDA (1)
6,893,661 Controlled release formulations using intelligent polymers 3 1998
 
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (1)
5,840,756 Pharmaceutical composition of L-DOPA ester 23 1996
 
OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (4)
4,680,323 Method and composition for the preparation of controlled long-acting pharmaceuticals for oral administration 33 1983
4,775,535 Method of preparing controlled long-acting pharmaceutical formulations in unit dosage form having uniform and comparable bioavailability characteristics 22 1986
4,855,143 Method of preparing controlled long-acting pharmaceutical formulations in unit dosage form having uniform and comparable bioavailability characteristics 21 1988
6,264,974 Buccal and sublingual administration of physostigmine 2 1998