Maytansinoids, pharmaceutical compositions thereof and methods of use thereof
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United States of America Patent
Stats
-
Apr 7, 1981
Grant Date -
N/A
app pub date -
Nov 9, 1979
filing date -
Nov 14, 1978
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Novel maytansinoids of the formula: ##STR1## wherein R.sup.1 is hydrogen atom, an alkyl group which may optionally be substituted or a group of the formula: --A.sup.1 --Y.sup.1 wherein A.sup.1 is an alkylene group or a bond, and Y.sup.1 is a cycloalkyl, phenyl, indolyl or imidazolyl group which may optionally be substituted, R.sup.2 is hydrogen atom, an alkyl, cycloalkyl or benzyl group, R.sup.3 is hydrogen atom, an alkyl group which may optionally be substituted, alkoxy, bornyloxy, isobornyloxy, benzyloxy group or a group of the formula: --A.sup.2 --Y.sup.2 wherein A.sup.2 is an alkylene group or a bond, and Y.sup.2 is an alicyclic hydrocarbon, phenyl or heterocyclic group which may optionally be substituted, provided that R.sup.3 is not an unsubstituted C.sub.1-4 alkyl group when both R.sup.1 and R.sup.2 are methyl groups, have antimicrobial antimitotic and antitumor activities.
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