Monensin urethane derivatives
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United States of America Patent
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-
Apr 21, 1981
Issued Date -
N/A
app pub date -
Sep 20, 1979
filing date -
Nov 29, 1978
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Monensin urethane derivatives of the formula ##STR1## wherein R.sub.1 is hydrogen, wherein R.sub.4 is alkyl, aryl, alkylaryl, arylalkyl, haloaryl, nitroaryl, haloarylalkyl, alkoxyaryl, aryloxyaryl, arylcycloalkyl, acylaryl and cycloalkyl; R.sub.2 is methyl or ethyl and R.sub.3 is --CONHR.sub.4 and their pharmaceutically acceptable salts. The compounds exhibit antimicrobial activity and activity as growth promotant agents in ruminants. Further activities for this series of compounds are anticoccidial activity, antihypertensive activity, antimalarial activity and as agents in the treatment of swine dysentery. Also disclosed are a fermentative process and a semisynthetic process for producing the urethane derivatives.
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